BMS-599626 盐酸盐

中文名	BMS-599626 (Hydrochloride)
英文名	BMS-599626 (Hydrochloride)
别名	BMS-599626 盐酸盐 HER1和HER2高效抑制剂(BMS-599626 HYDROCHLORIDE) [4-[[1-[(3-氟苯基)甲基]-1H-吲唑-5-基]氨基]-5-甲基吡咯并[2,1-F][1,2,4]三嗪-6-基]氨基甲酸 (3S)-3-吗啉基甲基酯盐酸盐
英文别名	AC480 AC-480 CS-173 AC480 HCl BMS599626 BMS 599626 BMS-599626 HCl BMS-599626 HCL BMS-599626 (AC480) BMS-599626 (Hydrochloride) BMS-599626 hydrochloride(AC480 [4-[[1-[(3-Fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid (3S)-3-morpholinylmethyl ester hydrochloride
CAS	873837-23-1
化学式	C27H28ClFN8O3
分子量	567.0144232
溶解度	10毫米DMSO
存储条件	-20℃
体外研究	BMS-599626 Hydrochloride inhibits the proliferation of tumor cells that are dependent on HER1/HER2 signaling.BMS-599626 Hydrochloride (0.03-8 μM; 1 huors) results in the inhibition of receptor autophosphorylation, as well as MAPK phosphorylation, with IC 50 s of 0.3 and 0.22 μM, respectively, in Sal2 cells which express a CD8HER2 fusion protein. BMS-599626 Hydrochloride abrogates HER1 and HER2 signaling and inhibited the proliferation of tumor cell lines that are dependent on these receptors, with IC 50 s in the range of 0.24 to 1 μM.In GEO cells, HER1 phosphorylation is stimulated by treatment with EGF and is inhibited by BMS-599626 Hydrochloride (IC 50 =0. 75 μM).There is also nearly complete inhibition of EGF-dependent MAPK (0. 8 μM) but only partial inhibition of AKT signaling.The latter likely reflects the activation of AKT by multiple upstream signals.Treatment of N87 cells with BMS-599626 Hydrochloride leads to the inhibition of HER2 (0. 38 μM), which is expressed to a high level because of gene amplification, as well as MAPK and AKT phosphorylation (0.35 μM for both). At the molecular level, in HN-5 cells the agent (BMS-599626 Hydrochloride) inhibits the expression of pEGFR, pHER2, cyclins D and E, pRb, pAkt, pMAPK, pCDK1 and 2, CDK 6, and Ku70 proteins. BMS-599626 Hydrochloride also induced accumulation of cells in the G1 cell cycle phase, inhibited cell growth, enhanced radiosensitivity, and prolonged the presence of γ-H AX foci up to 24 h after radiation.

BMS-599626 盐酸盐 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	1.764 ml	8.818 ml	17.636 ml
5 mM	0.353 ml	1.764 ml	3.527 ml
10 mM	0.176 ml	0.882 ml	1.764 ml
5 mM	0.035 ml	0.176 ml	0.353 ml

最后更新：2024-01-02 23:10:35

北京索莱宝科技有限公司

现货供应

产品名: BMS-599626 Hydrochloride 去供应商网站查看询盘
CAS: 873837-23-1
产地: 北京
包装: 盒
规格: IB3510-5mg,5mg
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库存: 现询
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上海吉至生化科技有限公司

现货供应

产品名: BMS-599626 去供应商网站查看询盘
CAS: 873837-23-1
产地: 中国上海
包装: 5mg
规格: 99%
价格: 835.00
库存: 现货
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产品描述: 中文名：BMS-599626 英文名:BMS-599626 Hydrochloride CAS:873837-23-1 规格:99% 产地:中国上海

上海麦克林生化科技股份有限公司

现货供应

产品名: [4-[[1-[(3-氟苯基)甲基]-1H-吲唑-5-基]氨基]-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基]氨基甲酸 (3S)-3-吗啉基甲基酯盐酸盐去供应商网站查看询盘
CAS: 873837-23-1
产地: 上海
规格: B899640
价格: 25mg-1061,10mg-641,5mg-370
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
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上海源叶生物科技有限公司

产品名: BMS-599626 (Hydrochloride) 去供应商网站查看询盘
CAS: 873837-23-1
产地: 上海
规格: 99%
价格: 5mg 710,10mg 1230,50mg 3600,100mg 6000
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
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